The effect of zoledronic acid in the treatment of unstable and osteoporotic intertrochanteric fractures in elderly
CHEN Rui-xiong
WANG Xiao-feng
ZHANG Zhi-wen
WU Zhe-hui
QIU Long-hai
Abstract：Objective To explore the effect of zoledronic acid in the treatment of unstable and osteoporotic intertrochanteric fractures in elderly .Methods Two hundred and twenty elderly patients of unstable and osteopo-rotic intertrochanteric fracture were collected from Apr .2010 to Nov.2014 in our hospital .They were randomly di-vided into two groups depending on the anti-osteoporosis drugs:the zoledronic acid group ( the observation group ,n =110) and the calcitonin group (the control group,n=110).The hospitalization time,the fracture healing time, hip function outcome ( Harris score ) , excellent and good rate , the VAS score , the postoperative complications and bone mineral density ( BMD) of lumbar and hip were recorded and evaluated .Results Patients of the two groups obtained more than 1 year follow-up.For the hospitalization time,the fracture healing time,hip function outcome (Harris score),excellent and good rate,the VAS score,the postoperative complications,the differences had no statis-tical significance between two groups ( P>0.05 ) .BMD of lumbar and hip in the observation group were ( 0.81 ± 0.05)g/cm2 and (0.79 ±0.06)g/cm2 respectively.And BMD of lumbar and hip in the control group were (0.77 ± 0.07)g/cm2 and(0.74 ±0.07)g/cm2 respectively.BMD of lumbar and hip in the observation group were higher than those in the control group(P<0.05).Conclusion Zoledronic acid has superior effect in unstable and osteo-porotic intertrochanteric fractures .It can improve BMD but does not affect the recovery of the fracture healing and hip function and it is deserved to be promoted .
Keywords：intertrochanteric fractureosteoporosiszoledronic acidelderly
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 45-48 )