Effects of pyruvate-oral rehydration solution on lactate level and plasma volume during oral resuscitation in dogs with 50%TBSA full thickness burn injury
BAI Xiao-dong
LIU Wei-wei
ZHOU Fang-qiang
HU Sen
Abstract：Objective To study the effects of oral pyruvate sodium-glucose-electrolyte solution ( PGES) on lactate level and plasma volume during oral resuscitation in dogs with burn injury .Methods In comparison of Pyr-GES with NaHCO3-GES,beagle dogs with intubation of the carotid artery and jugular vein for 24h were subjected to a 50%TBSA burns,and were divided into three groups:burn injury without fluid resuscitation (NR,n=8),and two oral fluid resuscitation(each n=8),in which dogs were given either Pry-GES(OP) or NaHCO3-GES (OH) with volume and rate consistent with the Parkland Formula .The arterial and venous blood were drawn at different time points after injury,and then mean arterial pressure (MAP),circulating plasma volume (PV),dp/dtmax,LAC,pH and PaO2 under non anaesthesia state were observed .Results The hemodynamic parameters (MAP,PV,dp/dt-max,pH,LAC,PaO2 ) were significantly reduced after burns .Group NR continued to decline until death;while those of two oral resuscitation groups had improved gradually (P<0.05),OP group was significantly superior to OH group (P<0.05).Conclusion The Pyr-GES may be superior to the standard NaHCO3-GES in the improvement of MAP,PV,dp/dtmax,pH,LAC,PaO2 during oral resuscitation in dogs with 50%TBSA full thickness burn injury .
Keywords：burnsshockpyruvateplasma volumeacidosis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 30-34 )