A comparative study of the effect of rivaroxaban and physical treatment on prevention of venous thromboembolism after lumbar interbody fusion
LUO Chun-mei
FENG Cheng-cheng
MIU Dan
CHEN Yu
ZHANG Zheng-feng
Abstract：Objective To evaluate the preventive effects of rivaroxaban and intermittent pneumatic compression combined with elastic stocking on venous thromboembolism(VTE) after lumbar interbody fusion.Methods Two hun-dred and three patients who underwent lumbar interbody fusion in our departmentl from Jan.2013 to Jul.2013 were involved in the study.Rivaroxaban( group A,101 cases) or intermittent pneumatic compression combined with elas-tic stocking( group B,102 cases) were applied for 7 d after surgery.The color Doppler ultrasound examination of lower extremities,D-dimer,PT and APTT were evaluated before and at 7 d after surgery.Postoperative drainages within 48 h and the VTE and adverse reactions within 90 d postoperatively were also recorded.Results There was no VTE of lower extremity in group A and 2 in group B(13 d and 45 d,respectively) within 90 d postoperatively. However,there was no significant difference between the two groups(P=0.498).The D-dimer value increased in both groups after surgery(P<0.001).The D-dimer in group B was 2.2 times of that in group A at 7 d after surgery.There was no significant difference in drainage volumes,the levels of PT and APTT and the adverse reactions postoperatively between group A and group B(P>0.05).Conclusion Both rivaroxaban and intermittent pneumatic compression combined with elastic stocking are effective and safe for the prevention of VTE after lumbar interbody fusion.
Keywords：venous thromboembolismlumbar interbody fusionrivaroxabanintermittent pneumatic com-pressionelastic stocking
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 652-655 )