Prophylactic effect of Vitamin C on the complex regional pain syndrome:a meta analysis
HAO Peng
DU Chuan-chao
CHENG Hua
QIU Hai-bin
Abstract：Objective To evaluate the prophylactic effect of Vitamin C on the complex regional pain syn-drome( CRPS) after extremities trauma or surgery .Methods The databases used for this review included: Ovid MEDLINE,CINAHL,Ovid EMBASE,the Cochrane Database and CNKI .The literatures about peri-operative patients with daily doses of no less than 500mg of vitamin for preventing CRPS were retrieved .Results After screening with inclusion and exclusion criteria ,we selected 4 studies which were about upper extremities trauma and 1 study which was about foot and ankle surgery .All the 5 studies met the minimum heterogeneity without interventions ( Tau2 =0.00).The quantitative analysis showed an odds ratio of 0.21(95%confidence interval =0.12, 0.34) when daily vitamin C of at least 500 mg was given immediately after the extremity surgery or injury and was continuously applied for the following 50 days.Conclusion Taking vitamin C immediately after extremity trauma or surgery can effec-tively prevent the occurrence of CRPS .
Keywords：extremities traumaperi-operative periodpain syndromevitamin-Cprophylaxismeta-analysis
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 595-598 )