Effect of large doses of arginine supplementation on changes of relative parameters and on the occurrence of sepsis in severe burn
WANG Hao
LIU Jiang-tao
YE Wei-qi
Abstract：Objective To observe the effect of large doses of arginine ( Arg) supplementation on interleu-kin-16(IL-16),interleukin-17(IL-17),serum C reactive protein(CRP) and the occurrence of sepsis in severely burned patients . Methods Totally 201 patients with severe burn were randomly divided into the experimental group(n=112) and the control group (n=89).The control group received Arg with a dose of 0.1g/kg,and the experimental group received Arg with a dose of 0.4g/kg.The changes of serum IL-16,IL-17,and CRP were ob-served in both groups before treatment and at 3,7,14d after treatment.Also,the incidence of sepsis were statistical-ly analyzed.Results At 7d after treatment,the levels of IL-16,IL-17,and CRP in the experimental group were sig-nificantly lower than those in the control group ( P<0.01);and the incidence of sepsis in the experimental group was significantly lower than that in the control group (P<0.05).Conclusion High dose of Arg supplementation can reduce the inflammatory response in severe burn patients and reduce the incidence of sepsis ,which may be achieved by reducing the levels of serum CRP ,IL-17,and IL-16.
Keywords：burnsepsisarginine
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 585-587 )