Effects of Alprostadil on coagulation system in patients undergoing skin flap transplantation

SHI Jian; ZHAO Gang; CHENG Chun-sheng; ZHA Zhu-qing

doi:10.3969/j.issn.1009-4237.2016.09.015

Abstract：Objective To investigate the effects of Alprostadil at different time points on coagulation system in patients undergoing skin flap transplantation.Methods Two-hundred patients undergoing free skin flap trans-plantation from Feb.2012 to Aug.2014 in our department were selected and equally divided into conventional treat-ment group and Alprostadil group.Patients in the conventional group were treated with low molecular dextran and heparin for expansion and anticoagulation.Patients in the Alprostadil group were added with intravenous injection of Alprostadil on the basis of conventional treatment from the day of surgery for 7d.The turgidity of skin flap,pain score,vascular crisis occurrence,and determination of coagulation function in patients were observed at 24h and 72h after surgery.Results The turgidity of skin flap in the Alprostadil group was significantly lower than that of the conventional group at 24h and 72h after surgery(P<0.05).The pain score in the Alprostadil group was signifi-cantly lower than that of the conventional group at 72h after surgery(P<0.05).The vascular crisis occurrence rate in the Alprostadil group and the conventional group was 1.0% and 5.71%,respectively at 72h after surgery.The vascular crisis incurrence rate in the Alprostadil group was significantly lower than that of the conventional group at 72h after surgery(P =0.02).The coagulation function index showed no significant difference between the two groups at the same time point(P=1.18).Conclusion The administration of Alprostadil after free skin flap trans-plantation can keep the stability of coagulation system in patients,inhibit the aggregation of platelets,prevent the tur-gidity and pain,reduce the vascular crisis incurrence rate and have good clinical application values.