Effects of insulin intensive therapy on early cognitive function and prognosis of elderly patients with severe burn complicated with stress hyperglycemia
SUN Yong
FAN Wei
WANG Guang-jun
YU Guo-jun
ZHANG Da-wei
Abstract：Objective To investigate the effects of insulin intensive therapy on early cognitive function, contents of NSE and S100βand prognosis of elderly patients with severe burn complicated with stress hyperglycemi-a.Methods Eighty elderly patients with severe burn complicated with stress hyperglycemia were randomly divided into intensive group( n=40) and conventional group( n=40) .Insulin intensive therapy was given to the patients in the intensive group to maintain blood glucose level at 6.0-8.0mmol/L ofter admission.Blood glucose level of pa-tients in the conventional group was maintained at 8.1-10.0mmol/L under routine clinical treatment.MMSE( mini-mental state examination) score and the incidence rate of cognitive dysfunction were measured at the time of admis-sion(T0) and at 1d(T1),2d(T2),3d(T3),5d(T4),7d(T5) after treatment.Also,the serum contents of NSE and S100βwere determined at the same time as before.The incidence rates of MODS,sepsis,hypoglycemia and death were recorded in the two groups.Results MMSE scores in the intensive group were higher,while the incidence rates of cognitive dysfunction and the serum contents of NSE and S100βwere lower than those of the conventional group from T2-T5(P<0.05).Compared with T0,MMSE scores in the intensive group and conventional group were increased at T2-T5 and at T4-T5 respectively,while cognitive dysfunction and the serum contents of NSE and S100βwere decreased(P<0.05).Incidence rate of MODS and sepsis were obviously lower in the intensive group than the conventional group after insulin intensive therapy. Conclusion Insulin intensive therapy can improve cognitive function,reduce incidence rates of MODS and sepsis,and decrease serum contents of NSE and S100βof elderly pa-tients with severe burn complicated with stress hyperglycemia.
Keywords：burninsulinhyperglycemiacognitive dysfunctionelderly
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 549-552 )