Changes of insulin-like growth factor binding protein 1 (IGFBP-1) in patients with burn injury
FENG Deng-chao
GAO Dong-dong
YANG Xi-ming
Abstract：Objective To investigate the changes of insulin-like growth factor binding protein 1(IGFBP-1) in patients with burn injury.Methods Eighty-six adult patients with burn injury who were admitted in our hospital from Dec.2012 to Dec.2014 were selected as study subjects.Plasma was collected from the date of admission to 10 days after admission.The plasma levels of insulin,insulin-like growth factor-1( IGF-1) and IGFBP-1 were measured by ELISA.Phosphorylated IGFBP-1 was detected by Western Blotting.Results The plasma level of IGFBP-1 was positively correlated with the total body surface area( TBSA) .The plasma level of IGF-1 was decreased significantly with the increased degree of TBSA in burn patients.The plasma level of IGF-1 decreased within 72 h after burn in-jury.However,the mean IGFBP-1 level [(184 ±26) ng/mL] was significantly higher than that of normal health subjects [(16 ±4)ng/mL,P<0.05].The phosphorylated IGFBP-1 could be detected in plasma in patients with burn injury.Conclusion The changes of IGFBP-1 and persistent phosphorylation of IGFBP-1 in plasma of patients with burn injury are positively correlated with the severity of burn injury.The sustained phosphorylation of IGFBP-1 can inhibit the biological activity of IGF,and can be accepted as a predictor in predicting the prognosis of burn in-jury.
Keywords：burnsinsulinphosphorylated insulin-like growth factorprognosis
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 545-548 )