Application effect of skin soft tissue dilator and rhEGF in face and neck scar

QIN Dan-ying; SHEN Guo-liang; ZHAO Xiao-yu; QIAN Han-gen

Abstract：Objective To investigate effect of skin soft tissue dilator and recombinant human epidermal-growth factor ( rhEGF) in the treatment of face and neck scar.Methods From Mar.2013 to Feb.2015,50 patients with face and neck scar were selected and randomly divided into the observation group( n=24) and the control group (n=26).The control group was treated by skin and soft tissue dilator,and the observation group was treated by rhEGF and skin and soft tissue dilator.The indexes including dilation time,skin expansion rate,immediate retraction rate,hydroxyproline content and typeⅠ/Ⅲcollagen ratio were compared between the two groups.Results The expan-sion completion time and immediate retraction rates of the observation group were (32.97 ±5.11) d and (24.07 ± 4.21)%,respectively,which were significantly lower than those of the control group(P<0.05);the skin expansion rate in the observation group was (140.11 ±10.47)%,significantly higher than that of the control group,with statisti-cal difference(P<0.05);the hydroxyproline content of the observation group was (3.82 ±0.31)g/(mg· prot),sig-nificantly higher than that of the control group,with statistical difference( P<0.05);the typeⅠ/Ⅲcollagen ratio in the observation group was (2.03 ±0.21),significantly lower than that of the control group,with significant differ-ence(P<0.05).Skin flaps in the two groups were all survived with good effect.Conclusion Skin soft tissue di-lator and rhEGF for treating face and neck scar can achieve good clinical results,can shorten the expansion time and reduce the immediate retraction rate of soft tissue.It is worthy of wide application in clinical practice.