Effect of a new hemoglobin based oxygen carrier OC33 in severe hemorrhagic shock of pigs
ZANG Jia-tao
LI Tao
TIAN Kun-lun
ZHU Yu
LAN Dan
PENG Xiao-yong
LIU Liang-ming
Abstract：Objective To investigate the effect of the hemoglobin based oxygen carrier ,OC33,in severe hemorrhagic shock in pig models .Methods Eighteen severe hemorrhagic shock pig models (9 male pigs and 9 fe-males pigs of 8-10 years weighted from 25-30kg) were prepared from specified pathogens free (SPF) pigs by con-trolled blood depleting of 50%whole blood volume .And then model pigs were randomly divided into three groups , Ringer's solution team (LR),whole blood group (WB) and OC33 group.Model pigs were treated with correspond-ing solutions,and indexes including tissue oxygen delivery (DO2) and uptake (VO2),blood kinetics and myocardial kinetics,cardiac output and cardiac function were tested .Model pigs were sent back to observation ward after reme-dy and 24 hour survival time and survival rate were recorded .Statistical analysis was done to evaluate whether OC 33 could be used in severe hemorrhagic shock pig remedy .Results Indexes including DO 2 ,VO2 ,blood kinetics ,heart output,myocardial mechanic parameters (MAP,LVSP,LVEDP,+/-dp/dtmax ),heart function parameters (CO, CI,SI),survival rate and time of the OC33 group were better than those in the LR group .The 0.5g Hb/kg group had the best effect among the three OC33 groups,some indexes of this group were even similar with those of the WB group.Conclusion OC33 is a good candidate in severe hemorrhagic shock remedy for pig models .
Keywords：hemorrhagic shockoxygen carrierred blood cellhemoglobinanimal model
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 94-97 )