Efficacy of calcitonin combined with operation for the treatment of unstable distal radial fracture in elderly patients with osteoporosis
CHEN Zhong-yu
Abstract：Objective To observe the efficacy of calcitonin combined with operation for the treatment of unstable distal radial fractures in elderly patients with osteoporosis.Methods From Jan.2009 to Dec.2011,80 elderly patients with unstable distal radial fracture were randomly divided into two groups:the research group and the control group.Both groups were operated with volar locking compression plate fixation.Patients in the research group were treated with calcitonin dose of 50IU that was added to 100IU after 2 weeks,and caltrate D600 daily after operation,while patients in the control group were treated with caltrate D600 only.The drug administration time was three months in both groups.Bone healing was assessed with X ray and bone mineral density(BMD)was measured by dual energy X-ray absorptiometry.Modified Sarmiento scales,Mcbride scores,complications,adverse drug effect and subsequent fractures were recorded postoperatively.Results All patients were followed up for an average of 12 months.The modified Sarmiento scale showed excellent in 27 cases and good in 13 cases in the research group, while excellent in 23 cases and good in 17 cases in the control group.Wrist function was evaluated with modified Mcbride system,which showed excellent in 25 cases,good in 11 cases,and fair in 4 cases in the research group, while excellent in 13 cases,good in 19 cases,and fair in 9 cases in the control group.No significant difference was found between the two groups in BMD preoperatively(P >0.05).The changes in BMD were significantly different between the two groups after 6 months and 12 months after surgery(P <0.01).Conclusion Volar locking com-pression plate combined with calcitonin is an effective method for the treatment of unstable distal radial fractures in osteoporotic patients.It can enhance the internal fixation,promote bone healing,and improve the wrist function.
Keywords：radial fractureosteoporosisbone densitycalcitonininternal fixation
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 21-24 )