Effect of dexamethasone on C-reactive protein and endothelin-1 in patients with severe traumatic brain injury and clinical significance of the changes
LIU Guo-sheng
LUAN Xiao-zu
ZHU Ming
PENG Sai-liang
ZHAO Zhi-yong
Abstract：Objective To explore the effects of dexamethasone injection on C-reactive protein and endothe-lin-1 in patients with severe traumatic brain injury and clinical significance of the changes. Methods Seventy-eight patients with severe traumatic brain injury were randomly divided into dexamethasone treatment group and con-trol group with 39 patients in each group.All patients received conventional therapy and patients in dexamethasone treatment group were given an additional treatment with dexamethasone injection.Levels of C-reactive protein and endothelin-1 were monitored in all patients on day 1,3,5,7,and 14 after therapy.And Glasgow coma scale (GCS) were observed in all patients at the same time point.Results There was no obvious change in endothelin-1 on day 1 after therapy in either group (P>0.05).But obvious changes were found in C-reactive protein on day 1 after therapy in both groups(P<0.01).Compared with the control group,C-reactive protein and endothelin-1 in the dexamethasone treatment group decreased significantly on day 3,5,7 and 14 after therapy.There was no obvious change on GCS on day 1 after therapy in either group(P>0.05).Compared with the control group,GCS increased on day 3,5 and 7 after therapy(P<0.05).Conclusion Dexamethasone can significantly reduce the levels of C-reactive protein and endothelin-1 and improve GCS in patients with severe traumatic brain injury.
Keywords：brain injurydexamethasoneC-reactive proteinendothelin-1
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 403-406 )