The clinical effect of recombinant human growth hormone in the treatment of severe burn patients

LIU Wei-yuan; XU Xian-jun; CHEN Yan-tu

Abstract：Objective To explore the clinical effect of recombinant human growth hormone( rhGH) in the treatment of patients with severe burn.Methods In our hospital,84 severe burn patients were divided into the ex-perimental group and the control group.Forty-two patients in the experimental group were administered while the other 42 cases in the control group were given saline as placebo.Growth hormone before and after surgery,blood glucose,insulin,glucagon,and prealbumin(PA),total blood serum protein(Tb) and hospitalization time were ana-lyzed in all patients.Results In the 3rd day after the use of rhGH,blood growth hormone concentration in the con-trol group began to increase and was higher than that of the control group with significant difference ( P<0.05 ) . From the 10th day on,difference of PA and Tb in the serum of patients became obvious gradually.The hospitaliza-tion time of patients in the experimental group was less than that of the control group with statistically significant differences( P<0.05) .In addition,the content of cortisol and glucagon in two groups during the whole observation period showed no significant difference( P>0.05) .Conclusion rhGH has good clinical efficacy in the treatment of severe burn patients.It can reduce the incidence of adverse reaction and hospitalization time and is worthy of clinical application.