Effect of molecular weight of hydroxyethyl starch on neurogenic pain after spinal cord compression injury
LIU Hong-bo
SONG Zhen-quan
LIANG Guo-biao
WANG Zhi-jun
ZHAO Ming-guang
ZHAO Xu
LEI Wei
LI Bin
Abstract：Objective To study the effect of molecular weight of hydroxyethyl starch ( HES 130/0.4,Wan Men) on neurogenic pain after spinal cord compression injury .Methods Forty-eight adult male SD rats were ran-domly divided into four groups . The first group was sutured as the control group after removal of T 7-8 vertebral plate.The rest three groups of rats were given saline ,HES 40,HES 130/0.4 treatment as model of chronic spinal cord compression.Four groups were tested for paw withdraw pressure threshold (PWPT)and paw withdraw latency ( PWL) .Evens Blue ( EB) was intravenously injected and the EB content of spinal cord tissue was measured to ob -serve the blood spinal cord barrier (BSCB).Immunofluorescence and western blotting were adopted to observe the activation of astrocytes and microglia/macrophages .ELISA method was conducted to determine the expression of IL-1,IL-6 and TNF-α.Results HES 130/0.4 can alleviate abnormally permeable BSCB ,inhibit the inflammatory re-sponse in the injury site and down-regulate the expression of IL-1,IL-6 and TNF-α.After spinal cord injury ,PWPT and PWL decreased significantly .After HES 130/0.4 treatment,PWPT and PWL improved significantly .Conclu-sion HES 130/0.4 can relieve neurogenic pain complicated with spinal cord injury . Its mechanism may be through improving the abnormally permeable BSCB to suppress the inflammatory response in the injury site .
Keywords：spinal cord compression injuryinflammationblood spinal cordbarrierhydroxyethyl starch
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 154-159 )