4-phenyl butyric acid improves organ function against ischemia-hypoxia injury following shock
PENG Xiao-yong
LI Tao
LIU Liang-ming
ZHU Yu
LAN Dan
WU Yue
YANG Guang-ming
Abstract：Objective To investigate the effects of 4-phenyl butyric acid(PBA) on blood perfusion, vital organ and mitochondrial function of traumatic hemorrhagic shock rats .Methods With models of traumatic hemor-rhagic shock in 128 SD rats,64 female and 64 male with body weight ranged from 180g to 220g,the effects of PBA (5, 20,50 mg/kg) on the blood flow in liver and kidney , the function of the liver and kidney and its mitochondrial function were observed .Results The blood flow in liver and kidney was significantly reduced , the damage of liver and kidney function was detected after shock .PBA (20mg/kg) significantly increased the liver blood flow , and the renal blood flow in the three doses of PBA groups was higher than in lactated Ringer ’s solution (LR) group.PBA (20mg/kg) improved the liver and kidney function and decreased the index of liver and kidney function .Mean-while,PBA improved the decreased mitochondrial function in liver ,kidney and intestine after shock , and 20 mg/kg of PBA had a better effect .Conclusion PBA could improve blood perfusion in liver and kidney , restore the mito-chondrial function , and improve the vital organ function after traumatic hemorrhagic shock .
Keywords：traumahemorrhagic shockmitochondrial4-phenyl butyric acid
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 53-56 )