Influence of negative pressure-assisted wound therapy combined with topical oxygen therapy on the healing of wound surface of rabbits
LI Yong-zhong
HU Xiao-dong
LI Yun-fei
LEI Yun
Abstract：Objective To probe into the influence of regulated negative pressure-assisted wound therapy ( RNPT) combined with topical oxygen therapy ( TOT) on the healing of wound surface of wounded rabbits and pro-vide a experimental basis for its clinical application .Methods The wound models were built from skin resection on 40 randomly grouped New Zealand rabbits ( four groups , each group 10 ) . The wounds were treated by RNPT (negative pressure at -60mmHg),TOT(oxygen flow rate at 1L/min),RNPT +TOT(negative pressure at -60mmHg and oxygen flow rate at 1L/min) respectively and the control group was treated by routine enswathement . Observations were conducted for 28 days to record the numbers and time for healing .The average days for healing were calculated .Results The 10 wounds in the combined therapy group were all healed ,and the average time for healing was(18.6 ±2.4) days,which was significantly different from those of the other groups (the RNPT,TOT,and the control group ) .Conclusion The combined therapy of RNPT and TOT can facilitate wound healing .It can be applied as a new therapy for wound healing .
Keywords：woundnegative pressure-assisted wound therapyoxygen therapyhealing
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 9-12 )