Variation and significance of CD14 -/CD11 b+/CD33 +myeloid derived suppressor cells in elderly patients with multiple injuries
XUE Chen-chen
HE Fang-jun
ZHAO Jian-li
YIN Yan-hua
BAI Xiang-jun
LI Zhan-fei
Abstract：Objective To explore the variation and significance of CD 14 -/CD11b+/CD33 +myeloid de-rived suppressor cells ( MDSCs ) in elderly patients with multiple injuries . Methods Totally 26 young patients ( age 18-30 years ) and 21 elderly patients ( age >60 years ) with multiple injury were enrolled in this study . CD14 -/CD11b+/CD33 +MDSCs in peripheral blood were determined by flow cytometry ( FCM) at 1,3 and 7days after trauma.Serum transforming growth factor-β(TGF-β),interleukin-10 and C-reactive protein were determined by ELISA.Results The percentages of CD14 -/CD11b+/CD33 +MDSCs in peripheral blood of elderly patients at 3 and 7days after trauma were significantly higher than those of young patients (P<0.01),whereas did not differ significantly at 1 day after trauma between the two groups (P >0.05).The percentages of CD14 -/CD11b+/CD33 +MDSCs in peripheral blood of elderly patients with multiple injury were closely correlated with serum TGF -β,interleukin-10 and C-reactive protein level (P <0.05).Conclusion The percentages of CD14 -/CD11b+/CD33 +MDSCs in peripheral blood were significantly increased in elderly patients with multiple injuries .Our results indicated that accumulation of CD 14 -/CD11b+/CD33 +MDSCs may be an important mechanism of aging-related immune dysfunction in elderly patients with multiple injuries .
Keywords：traumacellinfectionimmune
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 215-218 )