Curative effect of bioactive artificial bone by nano-hydroxyapatite/polyamide 66 in treating limb bone defect in 87 cases

ZHU Mei-zhong; LI Xiao-bin; CHEN Tao

Abstract：Objective To observe the therapeutic efficacy and safety of the bioactive artificial bone by nano-hydroxyapatite/polyamide 66(n-HA/PA66) in treating the limb bone defect.Methods Eighty-seven cases of limb bone defect ,which resulted from limb cancellated bone compression fracture or metaphysis innocuousness tu -morectomy,were treated by padding bioactive artificial bone by nano-hydroxyapatite/polyamide 66(n-HA/PA66). X ray examination and CT were taken preoperatively and at 1 week,3,6,and 12 months postoperatively to observe the bone repair and bone graft fusion.Results All patients were followed up for 8 months (ranging 6-28 months). All patients got good wound healing ,without infection ,non-specify inflammatory reaction ,and serious complications . X-ray and CT examination revealed:bone defect area was well filled after operation ,its bone density was lower than the cancellous bone and the materials had clear boundary with the surrounding bone ;at 1 month after operation ,the bone defect density gradually increased ,showing blurring around the bone ,and a small amount of callus formation;at 3 months after operation ,the bone defect density was significantly increased with more callus fusion ;at 6 months after operation,the bone defect density was significantly increased with a large number of callus formation .The clinical bone healing time was at 3 to 7 months postoperatively (averaging 3.8 months),and the healing rate was 91.5%. Conclusion Bioactive artificial bone by nano-hydroxyapatite/polyamide 66 is a satisfactory and effective material for treating limb bone defect ,which can get expecting fusion without any adverse effect .