Risk factors analysis of pulmonary infection in NICU patients with severe brain injury

FENG Lin-sen; MA Jian-hua; JI Hai-ming; LIU Yi-chun; JI Ai-ping

Abstract：Objective To analyze the risk factors of pulmonary infection in severe brain injury patients in Neurosurgery Intensive Care Unit ( NICU) ,and to strengthen the clinical measures to prevent pulmonary infections . Methods The clinical data of 297 serious brain injury patients hospitalized in the NICU of Taixing Hospital Affilia-ted to Yangzhou University from Jan .2012 to Jan.2013 were analyzed retrospectively . The clinical prevention measures were taken according to the corresponding risk factors .Results The incidence rate of nosocomial pulmo-nary infection in severe brain injury patients was 19.9%.The pulmonary infection occurrence was correlated with patients’ age,the score of Glasgow Coma Scale,mechanical ventilation,tracheotomy,length of stay in NICU,com-bined underlying disease,operation treatment and smoking history (P<0.05).Gram-positive bacteria and multi-drug resistant bacteria infection were on the rise .Conclusion The advanced age,coma,mechanical ventilation, tracheotomy,long time staying in NICU ,combined underlying disease ,operation treatment , and smoking history are risk factors for the nosocomial pulmonary infections in patients with severe brain injury .Strict disinfection and isola-tion in NICU and appropriate preventive measures should be taken to reduce the incidence of pulmonary infection and to promote patients ’ rehabilitation .