Therapeutic value of aescine in traumatic acute lung injury
LIU Chao-pu
HU Ping
LI Chang-hua
WANG Xiao-li
XIAO Xia
Abstract：Objective To observe the therapeutic value of aescine in traumatic acute lung injury .Meth-ods Eighty patients with traumatic acute lung injury were randomly divided into aescine group (n=40) and con-trol group (n=40).Both groups was given routine treatment ,while the patients of the aescine group were given aescine (20mg,intravenous drip,once per 24 hours,for 12 days).The efficacy in both groups was assessed ,and their serum cytokines including tumor necrosis factor-α(TNF-α),interleukin-1(IL-1),interleukin-6 (IL-6)and in-terleukin-8(IL-8) were measured on the day before treatment and on the third day ,the sixth day,the ninth day and the twelfth day after treatment.Results There was no difference in TNF-α,IL-1,IL-6 and IL-8 levels between the two groups before treatment,which reduced more significantly on the sixth day after treatment in the aescine group than those in the routine group(P<0.05).There were significantly differences in the respiratory rate (RR),arteri-al partial pressure of oxygen (PaO2 ),arterial partial pressure of carbon dioxide (PaCO2 ) and PaO2/FiO2 after treat-ment between the two groups (P<0.05).Conclusion Aescine significantly inhibits the production of inflammato-ry cytokines,relieves acute pulmonary edema.Early administration of aescine can play an important role in the treatment of acute lung injury.
Keywords：traumalung injuryaescinecytokinetreatment
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 497-499 )