Protective effect of dexamethasone-the inhibitor of phospholipase A2 on endotoxemia animals
Abstract：Objective To explore the protective effects of dexamethasone(DXM)-the inhibitor of phospholipase A2(PLA2) on endotoxemia animals.Methods The animals were divided into 2 groups, i.e, endotoxemia group and DXM group. A rabbit endotoxemia model was used to measure the mean arterial pressure (MAP), survival rate after 8 hours, PLA2 activity of plasma and MDA level of the endotoxemia group and DXM group.Results After injected with endotoxin, MAP was decreased significantly with a survival rate of 57% after 8 hours; however, PLA2 activity of plasma and MDA level were significantly increased along with the aggravation of injury. As for the DXM pretreatment group, after injected with endotoxin, MAP was decreased less significantly than that of the endotoxin group(P<0.05); the PLA2 activity of plasma and the MDA level were significantly lower than those of the endotoxin group. The survival rate after 8 hours was as high as 70%.Conclusion The inhibitor (DXM) of PLA2 can elevate animal survival rate and survival time, improve hemodynamics and depress PLA2 activity. It suggests that DXM has positive effect on shock and general inflammation.
Machine-generated Keywords：
Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 116-118 )