Studies on anti-inflammatory response and immun osupression in posttraumatic patients with multiple organ dysfunction syndrome
Abstract：Objective Thirty-three traumatic patients［m ean injury severity score （ISS）21.8±5.8, 18 cases ISS 18-25,15 cases ISS≥25 ］with MODS were involved in this research to testify their parameters of CARS a nd immunity.Methods ELISA was utilized to detect plasma inter leukin(IL)-4，10，12，13.Results (1)IL-4 was negatively measu red in all patients whether SIRS, organ failure existed or not.(2) With the in crease of number of organ failure, level of IL-10 was elevated (P <0.05). IL-10 of SIRS and dead groups was very significantly increase d than that of non-SIRS group and the survival group.(3)High IL-12 concentrat ion was found in the survival group than that in the dead group (P＜0.05).(4)No significant difference of IL-13 was discovered bet ween SIRS and non-SIRS groups,but higher than the control group(P ＜0.05). Conclusion Posttraumatic patients with elev ated plasma IL-10 and low plasma IL-12 may be suscep tible to MODS with high mortality.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 7-9 )