Association of serum sCD163,S1P,and MPVLR with severity and prognosis in Mycoplasma pneumoniae pneumonia with atelectasis
Han Qing
Wu Xiaofeng
Jiang Min
Abstract：Objective To investigate the association of serum soluble cluster differentiation 163(sCD163),sphingosine-1-phosphate(S1P),mean platelet volume-to-lymphocyte ratio(MPVLR)and the severity and prognosis of Mycoplasma pneumoniae pneumonia with atelectasis.Methods A total of 120 children with Mycoplasma pneumoniae pneumonia admitted to our hospital from January 2021 to December 2024 were selected,and divided into a group with atelectasis(64 cases)and a group without atelectasis(56 cases)according to whether they were accompanied by atelectasis.The serum sCD163,S1P,MPVLR levels,arterial carbon dioxide partial pressure,and arterial oxygen partial pressure of all children were detected to observe the prognosis,and the predictive efficacy was analyzed by receiver operating characteristic(ROC)curve.Results Compared with the non-atelectasis group,serum levels of sCD163,S1P,and MPVLR in the atelectasis group were significantly increased(P<0.05).Compared with the non-atelectasis group,the partial pressure of carbon dioxide in arterial blood was higher in the atelectasis group(P<0.05),and the partial pressure of oxygen in arterial blood was lower(P<0.05).Through Pearson correlation analysis,the levels of serum sCD163,S1P,and MPVLR in children with Mycoplasma pneumoniae pneumonia accompanied by atelectasis were positively correlated with the partial pressure of carbon dioxide in arterial blood(P<0.05)and negatively correlated with the partial pressure of oxygen in arterial blood(P<0.05).Serum levels of sCD163,S1P,and MPVLR in the poor prognosis group were significantly higher than those in the good prognosis group(P<0.05).ROC curve analysis showed that serum sCD163 and S1P combined with MPVLR had a sensitivity of 91.42%,specificity of 58.73%,and AUC of 0.893 in predicting poor prognosis of children with Mycoplasma pneumoniae pneumonia with atelectasis.Conclusion Serum sCD163,S1P,and MPVLR are closely related to the severity of Mycoplasma pneumoniae pneumonia with atelectasis,and the combination of these three indicators showed good predictive performance for prognosis and worthy of clinical attention.
Keywords：Mycoplasma pneumoniae pneumoniaatelectasissoluble hemoglobin scavenger receptorsphingosine 1-phosphatemean platelet volume-to-lymphocyte ratio
Publication Date：2026-02-28
Online Publishing Date：2026-03-16(First online date of this platform, not the publication date of the document)
Pages：5( 75-79 )