Correlation between serum KL-6 and TIM-4 levels and the severity and prognosis of pulmonary tuberculosis
CHEN Jie
SUN Yier
ZHANG Hongtao
CAI Jing
Abstract：Objective To explore the correlation between levels of serum Krebs Von den Lungen-6(KL-6),T-cell immunoglobulin and mucin domain-containing molecule-4(TIM-4)and the severity and poor prognosis of pulmonary tuberculosis(TB)patients.Methods From July 2021 to July 2023,158 TB patients who visited Liyang Branch of Jiangsu Provincial People's Hospital were regarded as the TB group,and another 158 healthy people who underwent physical checkups were as the control group.Disease severity was assessed using the Bandim tuberculosis score,classifying patients into severe(n=61)and mild(n=97)groups.According to the prognosis,patients were divided into favorable(n=101)and poor(n=57)prognosis groups.Logistic regression analysis was used to analyze the influencing factors of prognosis of TB patients;Spearman's correlation analysis was used to analyze the correlation between serum KL-6 and TIM-4 levels and the severity of the TB,and the receiver operating characteristic curve was used to analyze the predictive efficiency of serum KL-6 and TIM-4 for prognosis of TB patients.Results Compared with the control group,the levels of serum KL-6 and TIM-4 in the TB group were markedly higher(P<0.05).Serum levels of KL-6 and TIM-4 were significantly elevated in the severe group compared to the mild group(P<0.05).Compared with the favorable group,the levels of serum KL-6 and TIM-4 in the poor group were significantly higher(P<0.05).Serum KL-6 and TIM-4 levels were both independent influencing factors for the poor prognosis of TB patients(P<0.05).The area under the curve(AUC)of serum KL-6 and TIM-4 in predicting the prognosis of TB patients was 0.789 and 0.803,respectively,the AUC of their combination was 0.914,and the predictive power of the combination was better than that of any single indicator(zcombination-KL-6=3.375,P=0.001,zcombination-TIM-4=3.514,P=0.000).Conclusion The levels of serum KL-6 and TIM-4 in TB patients increase,and they are closely related to the severity of disease and poor prognosis.Moreover,the combined prediction of these two biomarkers has a high predictive value for the poor prognosis of TB patients.
Keywords：tuberculosisKrebs von den Lungen-6T-cell immunoglobulin and mucin domain-containing molecule-4severity of diseaseprognosis
Publication Date：2026-02-28
Online Publishing Date：2026-03-16(First online date of this platform, not the publication date of the document)
Pages：5( 57-61 )