The diagnostic value of chest CT combined with serum miR-146a and miR-124-3p for pulmonary tuberculosis
GUO Zhou
ZHAN Zhaozhao
Abstract：Objective To explore and analyze the clinical diagnostic value of chest computed tomography(CT)combined with serum microribonucleic acid(miR-146a)and miR-124-3p for pulmonary tuberculosis.Methods From July 2021 to July 2024,106 patients with suspected tuberculosis admitted to our hospital were included as objects,and were assigned into tuberculosis group(n=62)and non tuberculosis group(n=44)according to their pathological test results.The 80 healthy individuals selected for medical examination were healthy controls.Logistic regression was applied to analyze the effects of miR-146a and miR-124-3p on pulmonary tuberculosis.The receiver operating characteristic(ROC)curve was plotted to analyze the diagnostic value of miR-146a and miR-124-3p for pulmonary tuberculosis.Kappa was applied to analyze the consistency between the combined examination of chest CT,serum miR-146a and miR-124-3p and the pathological examination results..Results The differences in serum miR-146a(1.00±0.11 vs.0.71±0.09 vs.0.88±0.10)and miR-124-3p(1.00±0.11 vs.0.66±0.08 vs.0.81±0.09)levels between the healthy control group,the non-tuberculosis group,and the pulmonary tuberculosis group were statistically significant(all P<0.05)MiR-146a[OR,95%CI(0.665,0.448-0.986)]and miR-124-3p[OR,95%CI(0.748,0.597-0.937)]were both protective factors that affected the occurrence of pulmonary tuberculosis(P=0.042,0.012).ROC curve results showed that the AUC for diagnosing pulmonary tuberculosis using miR-146a and miR-124-3p was 0.829 and 0.849,respectively.Chest CT had a high concordance Kappa value of 0.622 when compared to pathologic examination(P<0.05).The combined detection of chest CT,serum miR-146a and miR-124-3p had extremely high consistency with pathological examination,with a Kappa value of 0.828(P<0.05).The specificity,positive predictive value,and accuracy of the combination of the three in diagnosing pulmonary tuberculosis were obviously higher than those of chest CT,miR-146a,and miR-124-3p alone(P<0.05).Conclusion The levels of serum miR-146a and miR-124-3p are reduced in patients with pulmonary tuberculosis,and chest CT combined with serum miR-146a and miR-124-3p has certain clinical value in the diagnosis of pulmonary tuberculosis.
Keywords：chest computed tomographymicroribonucleic acid-146amicroribonucleic acid-124-3ppulmonary tuberculosisclinical diagnosis
Publication Date：2026-02-28
Online Publishing Date：2026-03-16(First online date of this platform, not the publication date of the document)
Pages：6( 51-56 )