Meta-analysis of seroprevalence of hepatitis E virus antibody in general population in China from 2015 to 2024
WU Xu
LI Jiawen
Subinur·Kurban
DOU Jing
CHEN Yuantong
WANG Xiaozhong
Abstract：Objective To understand the seroprevalence of hepatitis E virus antibody in general population in China from 2015 to 2024,and to provide reference for the development of public health prevention and control measures for hepatitis E virus(HEV).Methods The relevant literature on the seroepidemiological survey of HEV conducted in China from January 1,2015 to December 31,2024 was searched in PubMed,The Cochrane Library,Web of Science,EMbase,Wanfang Database,VIP and China National Knowledge Infrastructure.R 4.3.3 software was used for meta-analysis of the included literature.Results A total of 37 articles were included,including 31 anti-HEV IgM and 36 anti-HEV IgG.The results of meta-analysis showed that the seropositive rates of HEV IgM and IgG in the general population of China from 2015 to 2024 were 1.3%(95%CI:0.9%～1.6%)and 22.9%(95%CI:18.1%～27.7%),respectively.The results of subgroup analysis showed that the positive rate of anti-HEV IgM/G in both male and female were 1.2%(95%CI:0.7%～1.6%),21.9%(95%CI:15.6%～28.2%)and 1.0%(95%CI:0.7%～1.4%)/19.0%(95%CI:13.9%～24.1%),respectively.The serum positive rates of anti-HEV IgM and IgG increased with age.The provinces of Yunnan(anti-HEV IgM seroprevalence:2.9%,95%CI:0.6%～5.1%)and Qinghai(anti-HEV IgM seroprevalence:50.9%,95%CI:44.2%～57.5%)had the highest prevalence of HEV antibodies.The serum positive rate of anti-HEV fluctuated greatly in different years.The positive rates of anti-HEV IgM and IgG were the highest in 2017,which were 2.4%(95%CI:1.2%～3.5%)and 35.3%(95%CI:11.9%～58.7%),respectively.Conclusion The positive rate of anti-HEV serum in China is high,and there are significant differences between different regions.The positive rate of anti-HEV serum increases with age,and the public health prevention and control measures of HEV should be further strengthened.
Keywords：hepatitis E virusanti-HEV IgManti-HEV IgGseroprevalencemeta-analysis
Publication Date：2026-02-28
Online Publishing Date：2026-03-16(First online date of this platform, not the publication date of the document)
Pages：10( 34-43 )