Meta-analysis of cervical HPV infection status in Chinese women with HIV infection

YAO Juanjuan; WANG Fuchuan; YI Wei

doi:10.3969/j.issn.1007-8134.2026.01.005

Abstract：Objective Cervical cancer prevention and control among Chinese women of childbearing age infected with human immunodeficiency virus(HIV)have not received sufficient attention,and cervical cancer screening has not been incorporated into routine check-up items in HIV antiretroviral therapy clinics.This study aims to systematically evaluate the current status of human papillomavirus(HPV)infection and cervical lesions in Chinese HIV-infected women of childbearing age through meta-analysis,providing evidence-based data for developing targeted cervical cancer screening strategies.Methods Case-control studies on cervical cancer screening among Chinese HIV-infected women of childbearing age were systematically retrieved from databases such as CNKI,Wanfang,VIP,and PubMed.The incidence rates of high-risk HPV infection,low-risk HPV infection,multiple HPV infections,cervical low-grade lesions,and cervical high-grade lesions were extracted and analyzed for HIV-infected women(observation group)and HIV-negative women(control group).Statistical analysis was performed using STATA 15.0 software,and publication bias was assessed using Begg's test.Results A total of 16 articles(14 in Chinese and 2 in English)were included.The incidence rates of high-risk HPV infection,low-risk HPV infection,multiple HPV infections,cervical low-grade lesions,and cervical high-grade lesions in the observation group were 34.34%,14.20%,19.54%,14.00%,and 9.46%,respectively.In the control group,the incidence rates were 17.42%,8.15%,5.24%,4.11%,and 2.64%,respectively.Meta-analysis showed that high-risk HPV infection(OR=3.78,95%CI:2.36-3.36,P<0.05),multiple HPV infections,and cervical high-grade lesions were calculated using a random-effects model,with 95%confidence intervals of 2.82(2.36-3.36),3.78(1.99-7.18),and 3.15(1.51-6.58),respectively,and the statistical P-values were all<0.05,indicating significant differences.Low-risk HPV infection was calculated using a random-effects model,with a 95%confidence interval of 1.62(0.97-2.69),but the statistical P-value was>0.05,indicating no significant difference.Cervical low-grade lesions were analyzed using a fixed-effects model,with a 95%confidence interval of 2.94(2.05-4.22),and the difference was not statistically significant(P=0.08).The results indicate that HIV infection can significantly increase the risk of high-risk HPV infection,multiple HPV infections,and cervical high-grade lesions in Chinese women.Although the risk of low-risk HPV infection and cervical low-grade lesions appears elevated in HIV-infected Chinese women,the differences are not statistically significant.Conclusion HIV infection can significantly increase the risk of high-risk HPV infection,multiple HPV infections,and cervical high-grade lesions in Chinese women.