Application and influencing factors analysis of chemiluminescence-based T-cell test for tuberculosis infection in HIV-infected populations
JIANG Zuhuan
AI Wenbin
WANG Zhixi
Abstract：Objective To evaluate the diagnostic value of the chemiluminescence-based tuberculosis interferon-gamma assay(TB-IGRA)for active pulmonary tuberculosis in HIV-infected populations,and to analyze its sensitivity,specificity,and related influencing factors.Methods We retrospectively collected the clinical and laboratory data from 108 HIV-infected inpatients admitted to Xiaogan First People's Hospital between January 2021 to March 2023.Among them,76 cases were clinically diagnosed with active pulmonary tuberculosis(study group),while the remaining 32 patients without tuberculosis infection served as the control group.By comparing TB-IGRA test results between the 2 groups,we aimed to evaluate the diagnostic performance of TB-IGRA for tuberculosis in HIV-infected individuals.Furthermore,the study group was subdivided into negative group and the positive group based on TB-IGRA results.Spearman'rank correlation analysis was performed to assess the associations between HIV viral load,CD4+T-lymphocyte count,and TB-IGRA outcomes.Additionally,multivariate logistic regression analysis was conducted to indentify independent predictors of TB-IGRA sensitivity in this population.Results The sensitivity of TB-IGRA for diagnosing active pulmonary tuberculosis in HIV-infected individuals was 71.05%,with a specificity of 90.63%,positive predictive value(PPV)of 94.74%,negative predictive value(NPV)of 56.86%,and overall accuracy of 76.85%.Multivariate analysis revealed that age,CD4+T-lymphocyte count,and HIV viral load were independent predictors of TB-IGRA sensitivity.Conclusion TB-IGRA demonstrates high specificity and accuracy for diagnosing active pulmonary tuberculosis in HIV-infected individuals,but its sensitivity is relatively low.The test results are significantly by age,HIV viral load,and CD4+T-lymphocyte count.
Keywords：HIVtuberculosis T-cell testsensitivityaccuracy
Publication Date：2026-02-28
Online Publishing Date：2026-03-16(First online date of this platform, not the publication date of the document)
Pages：6( 14-18,23 )