Analysis of the effect of Huanglian Jiedu Tang combined with Maxing Shigan Tang and conventional Western medicine treatment on severe Mycoplasma pneumoniae pneumonia in children with toxic heat induced lung closure syndrome

ZHANG Baozhen; ZHAO Qiuxia; LI Haixia; Zhang Yun

doi:10.3969/j.issn.1007-8134.2025.06.008

Abstract：Objective To evaluate the clinical efficacy and safety of Huanglian Jiedu Tang combined with Maxing Shigan Tang integrated with conventional Western medicine therapy in children with severe Mycoplasma pneumoniae pneumonia(MPP)presenting with toxin-heat obstructing the lung syndrome.Methods A retrospective analysis was conducted on 100 children with severe MPP admitted to Yuncheng Central Hospital Affiliated to Shanxi Medical University between January 2023 and June 2024.According to the treatment received,patients were divided into a combination group(n=50)and a control group(n=50).The control group received conventional Western medicine alone,while the combination group received Huanglian Jiedu Tang and Maxing Shigan Tang in addition to conventional Western medicine.The two groups were compared in terms of clinical efficacy,time to improvement of symptoms and signs,levels of inflammatory markers,alveolar injury markers,and the incidence of adverse reactions.Results The total effective rate was significantly higher in the combination group than in the control group(P<0.05).The combination group showed shorter time to fever resolution,cough relief,disappearance of pulmonary wet rales,imaging absorption,and total hospital stay compared with the control group(P<0.05).After treatment,levels of C-reactive protein,white blood cell count,and procalcitonin decreased in both groups,with lower levels in the combination group(P<0.05).Levels of salivary liquefied glycoprotein antigen-6(KL-6)and surfactant protein D also decreased in both groups,with greater reductions in the combination group(P<0.05).The incidence of adverse reactions was lower in the combination group than in the control group(P<0.05).Conclusion The combination of Huanglian Jiedu Tang and Maxing Shigan Tang with conventional Western medicine has a significant therapeutic effect on severe MPP,which can shorten the duration of symptoms and hospital stay in children.It can effectively shorten the duration of symptoms and hospital stay,and its mechanism may be related to enhancing anti-inflammatory effects and reducing alveolar damage,while also minimizing the risk of adverse reactions caused by conventional Western treatments in children.