Association of peripheral blood CD4+,CD8+ T-cell levels and CD4+/CD8+ ratio with coronary artery stenosis severity in patients with HIV infection and coronary heart disease
GAO Wenjun
HE Yuanqiang
SHEN Jie
WU Yingjie
WANG Weiying
XU Zhaoyuan
Abstract：Objective To investigate the correlation of peripheral blood CD4+and CD8+T-cell counts and the CD4+/CD8+ratio with the degree of coronary artery stenosis and adverse prognosis in patients with human immunodeficiency virus(HIV)and comorbid coronary heart disease.Methods A retrospective analysis was conducted on the clinical data of 59 HIV-infected patients with coronary heart disease admitted to the Department of Cardiology at the Third People's Hospital of Kunming from 2020 to 2023.The severity of coronary artery stenosis was assessed using the Gensini score,and patients were classified into mild,moderate,and severe groups based on the Gensini score.The CD4+,CD8+T cell counts,and CD4+/CD8+ratios were compared among the 3 groups.Follow-up was performed to record major adverse cardiovascular events(MACE)in HIV-infected patients with acute coronary syndrome after discharge,and patients were divided into MACE and non-MACE groups.The CD4+,CD8+T cell counts,and CD4+/CD8+ratios were compared among the 2 groups.Results In patients with HIV infection and comorbid coronary heart disease,the severe coronary stenosis group exhibited significantly lower CD4+T-cell counts and a lower CD4+/CD8+ratio compared to the mild stenosis group(P<0.05).Additionally,the MACE group demonstrated significantly lower CD4+T-cell counts than the non-MACE group(P<0.05).Conclusion Lower CD4+T-cell counts and CD4+/CD8+ratios in patients with HIV and comorbid coronary heart disease are associated with a greater degree of coronary artery stenosis.Furthermore,decreased CD4+T-cell counts may be correlated with the occurrence of MACE in HIV patients with acute coronary stenosis.
Keywords：CD4+ T-cellsHIV infectioncoronary stenosismajor adverse cardiovascular events
Publication Date：2025-12-30
Online Publishing Date：2025-12-30(First online date of this platform, not the publication date of the document)
Pages：4( 540-543 )