Analysis of clinical characteristics in 431 HIV/AIDS patients with sepsis
XIAO Qiuye
ZHENG Yeqing
HUANG Tian
WEI Yinduo
ZOU Jun
Abstract：Objective To analyze the clinical characteristics of HIV/AIDS patients with sepsis,and to provide reference for the early diagnosis and treatment of HIV/AIDS patients with sepsis.Methods HIV/AIDS patients with sepsis admitted to Nanning Fourth People's Hospital from January 2021 to December 2022 were selected as the study subjects.Based on 30-day clinical outcomes,they were divided into a survival group and a death group.General data,infection distribution,and laboratory test results were compared between the two groups,and pathogen distribution was analyzed.Results A total of 431 patients were included,with 269(62.4%)in the survival group and 162(37.6%)in the death group.Among them,383(88.9%)patients had multiple infections,with the respiratory system being the most common site of infection.The death group had significantly higher age,bleeding rate,shock rate,organ failure rate,sequential organ failure assessment(SOFA)score,proportion of comorbid malignancies,and proportion of cryptococcal antigenemia compared to the survival group(P<0.05).The survival group had higher body mass index,proportion of comorbid syphilis infection,and hospitalization duration than the death group(P<0.05).The death group also had higher rates of central nervous system infections and multi-organ infections(P<0.05).Laboratory results showed that the death group had significantly higher white blood cell count,procalcitonin,C-reactive protein,absolute neutrophil count,lactate,lactate dehydrogenase,and prothrombin time compared to the survival group(P<0.05).Conversely,hemoglobin,albumin,and CD4+T-cell counts were lower in the death group(P<0.05).In terms of pathogens,351(81.4%)patients had positive pathogen cultures,with 199(56.7%)showing two or more pathogens.Fungal infections predominated,with the most common pathogens being Candida albicans(180 cases,25.8%),Talaromyces marneffei(119 cases,17.1%),Klebsiella pneumoniae(54 cases,7.7%),Mycobacterium(45 cases,6.5%),and Escherichia coli(36 cases,5.2%).Conclusion HIV/AIDS patients with sepsis primarily present with multiple infections,most commonly in the respiratory system.Fungal infections are predominant,with diverse pathogen profiles.Treatment should involve broad-spectrum and combined antimicrobial therapy.
Keywords：human immunodeficiency virusacquired immunodeficiency syndromesepsisclinical charateristic
Publication Date：2025-12-30
Online Publishing Date：2025-12-30(First online date of this platform, not the publication date of the document)
Pages：6( 534-539 )