Changes in serum HBP,MMP-2,and suPAR levels in children with Mycoplasma pneumoniae pneumonia and their predictive value for prognosis
Zhang Ying
Wang Liyan
Zhang Ling
Abstract：Objective To investigate the changes in the expression levels of heparin binding protein(HBP),matrix metalloproteinase-2(MMP-2),and soluble urokinase type plasminogen activator receptor(suPAR)in the serum of children with and suPAR were independent risk factors for poor prognosis in children with MPP(P<0.05).ROC curve analysis indicated that the area under the curve(AUC)of the combined detection of serum HBP,MMP-2,and suPAR for diagnosing poor prognosis in MPP patients was 0.985,and its diagnostic efficacy was significantly superior to that of single index detection(z=1.971,2.545,2.356,P<0.05).Conclusion Elevated serum HBP,MMP-2,and suPAR levels in children with MPP are closely related to poor prognosis.Combined of the three tests showed high predictive value for adverse outcomes in children with MPP.
Keywords：Mycoplasma pneumoniae pneumoniaheparin binding proteinmatrix metalloproteinase 2soluble urokinase type plasminogen activator receptorprognosis
Publication Date：2025-10-30
Online Publishing Date：2025-11-19(First online date of this platform, not the publication date of the document)
Pages：6( 472-477 )