Effects of Kangfuxin liquid combined with Bedaquiline on pulmonary function,immune function and nutritional status in patients with multidrug-resistant pulmonary tuberculosis
LI Na
REN Xinxin
CUI Dan
LIU Pengchong
ZHAO Jie
FENG Xiuli
Abstract：Objective To investigate the impacts of the combination therapy of Kangfuxin liquid and Bedaquiline(BDQ)on the lung function,immune function,and nutritional status in patients with multidrug-resistant pulmonary tuberculosis.Methods From January 2022 to December 2023,150 patients with multidrug-resistant pulmonary tuberculosis who seek treatment in our hospital were assigned into a conventional group,a BDQ group,and an innovative group via a random number table.The conventional group received treatment with conventional drugs,the BDQ group received treatment with BDQ,while the innovative group received treatment with Kangfuxin liquid in addition to BDQ group treatment.After 24 weeks of treatment,the clinical efficacy(cavity improvement rate,lesion absorption rate,sputum negative conversion rate)and adverse reactions(peripheral neuropathy,gastrointestinal reactions,QT interval prolongation,bone pain)were compared;in addition,the pulmonary function[forced vital capacity in one second(FEV1%),maximum ventilation per minute(MVV%),and forced vital capacity(FVC%)],nutritional status(nutritional risk score,body mass index,hemoglobin,albumin),and immune function(CD4+T cells,CD8+T cells,CD4+/CD8+)of both groups before and after treatment were tested.Results The cavity improvement rate,sputum negative conversion rate,and lesion absorption rate of the BDQ group were all higher than those in the conventional group after 24 weeks of treatment(P<0.05),while the cavity closure rate,sputum negative conversion rate,and lesion absorption rate of the innovative group were all higher than those in the BDQ group(P<0.05).The FEV1%,MVV%,FVC%,CD4+T cells,CD4+/CD8+,body mass index,hemoglobin,and albumin levels of both groups increased compared to before treatment(P<0.05),while CD8+T cells and nutritional risk score decreased compared to before treatment(P<0.05),and the difference between before and after treatment in the BDQ group was greater than that of the conventional group(P<0.05),while the difference between before and after treatment in the innovative group was greater than that of the BDQ group(P<0.05).There was no significant difference in the total adverse reactions among the 3 groups(P>0.05).Conclusion The combination of Kangfuxin liquid and BDQ can improve the efficacy and safety of multidrug-resistant pulmonary tuberculosis patients,and improve their symptoms,pulmonary function,immune function,and nutritional status.
Keywords：Kangfuxin liquidbedaquilinemultidrug-resistant pulmonary tuberculosispulmonary functionimmune functionnutritional status
Publication Date：2025-10-30
Online Publishing Date：2025-11-19(First online date of this platform, not the publication date of the document)
Pages：6( 454-459 )