Epidemiological and genotyping analysis of human papillomavirus infection in 316 patients with condyloma acuminatum

LIU Jiaqi; HU Meili; YANG Kai; YANG Jinlan; HE Yue; ZHANG Shan; YAN Feng

doi:10.3969/j.issn.1007-8134.2025.05.005

Abstract：Objective To investigate the epidemiological characteristics and genotype distribution of human papillomavirus(HPV)infection among patients with condyloma acuminatum(CA)in Baoding region.Methods total of 316 CA patients admitted to Baoding Maternal and Child Health Hospital between January 2019 to October 2023 were enrolled.We analyzed the distribution of HPV genotypes,the prevalence of low-risk(LR),high-risk(HR),and single-type HPV infections across different age groups,as well as the distribution of multiple HPV infections.Results Among the 316 CA patients,289 tested positive for HPV.The age distribution of HPV-positive patients was:≤20 years(97,33.56%),21～30 years(31,10.73%),31～40 years(38,13.15%),41～50 years(82,28.37%),and≥51 years(41,14.19%).LR HPV infections accounted for 42.21%(122/289),HR HPV for 83.39%(241/289),single HPV infection for 51.90%(150/289),and multiple infection for 48.10%(139/289).HPV6(15.57%)and HPV11(11.42%)are the main LR HPV infections in patients with genital warts.The predominant LR-HPV genotypes were HPV6(15.57%)and HPV11(11.42%),predominantly affecting patients aged≤20 years(18.34%)and 41～50 years(10.73%).The predominant HR-HPV genotypes were HPV16(36.68%)and HPV18(30.10%),with higher prevalence in the≤20 years(30.80%)and 41～50 years(26.99%)groups.Single-type infections were mainly caused by HPV types 16(20.42%)and HPV18(12.11%),with patients aged≤20 years(22.84%)and 41～50 years(17.30%)being most affected.Multiple infections were primarily mixed-type HPV infections(22.15%).Conclusion HR HPV infectionsare the most common among CA patients in Baoding region.The predominant HPV subtypes are HPV6,HPV11,HPV16,and HPV18.The majority of affected patients are aged≤50 years,and infections frequently occur as mixed-type infections.