Effects of Kangfuxin liquid combined with Bedaquiline on pulmonary function,immune function and nutritional status in patients with multidrug-resistant pulmonary tuberculosis
PENG Xin
WANG Yao
SUN Miao
Abstract：Objective To investigate the correlation between serum A aisintegrin and metalloproteinase 10(ADAM10),microfiber associated protein 4(MFAP4)and the severity of high-risk compensated HBV-related liver cirrhosis(HBLC).Methods A prospective study was conducted on 120 patients with high-risk compensated HBLC from the Sixth Hospital of Harbin from January 2022 to January 2024,with a follow-up period of 1 year.Patients who developed acute decompensation(AD)or acute-on-chronic liver failure(ACLF)were included in the severe group,while those who did not develop AD or ACLF were included in the non-severe group.The clinical data,serum ADAM10,and MFAP4 levels were compared between the two groups to analyze the relationship between serum ADAM10,MFAP4,and severe progression in high-risk compensated HBLC patients,as well as their predictive value.Results During a 1-year follow-up,2 cases were lost to follow-up,31 cases progressed to severe,and 87 cases remained non-severe.The duration of HBLC in the severe group was longer than that in the non-severe group,and the HBV-DNA viral load,MELD score,serum ADAM10,and MFAP4 levels were higher in the severegroup than in the non-severe group(P<0.05).There was a positive nonlinear correlation between serum ADAM10,MFAP4,and severe progression in high-risk compensated HBLC patients(Ptrend<0.05,Pnonlinear<0.05).Serum ADAM10 and MFAP4 were independent influencing factors of the severity of high-risk compensated HBLC patients,and had significant interaction with HBLC course,HBV-DNA viral load and MELD score(P<0.05).The area under curve(AUC)of ADAM10 and MFAP4 in predicting the severity of high-risk compensated HBLC was 0.767 and 0.740,respectively.The AUC of combined prediction was 0.890,which was significantly better than that of ADAM10 and MFAP4 alone(P<0.05).Conclusion Serum ADAM10 and MFAP4 exhibit a positive non-linear correlation with the severity of high-risk compensated HBLC patients,and have good predictive value,and the combined predictive value is higher.
Keywords：HBV-related liver cirrhosishigh-riskcompensatory periodseverityA aisintegrin and metalloproteinase 10microfiber associated protein 4
Publication Date：2025-10-30
Online Publishing Date：2025-11-19(First online date of this platform, not the publication date of the document)
Pages：7( 422-428 )