Risk factors for lower respiratory tract infection in ICU patients undergoing tracheostomy and the early predictive value of combination of serum IP-10 and AAG
ZHENG Ran
ZHANG Jie
SUN Chen
BIAN Xindi
JIA Yutong
Abstract：Objective To analyze the risk factors of lower respiratory tract infection and the predictive value of interferon gamma inducible protein 10(IP-10)and alpha 1-acidic glycoprotein(AAG)in the intensive care unit(ICU)patients undergoing tracheostomy.Methods From March 2019 to September 2024,296 patients who underwent ICU tracheostomy in our hospital were included as subjects.They were separated into an infected group(n=119)and an uninfected group(n=177)based on the occurrence of lower respiratory tract infection,and the infected group was divided into mild group(n=58),moderate group(n=37)and severe group(n=24)according to the extent of the disease.Logistic regression was applied to analyze the influencing factors of lower respiratory tract infections in ICU patients undergoing tracheostomy.Receiver operating characteristic(ROC)curve was plotted to analyze the predictive value of IP-10 and AAG for lower respiratory tract infections in ICU patients undergoing tracheostomy.Spearman correlation was used to analyze the correlation between IP-10,AAG levels and the severity of the disease.Results Compared with the uninfected group,the ICU stay time,airway opening time,the percentage of use of ventilator＞7 d,antibiotics＞2 classes,antibiotic use＞2 weeks and the levels of serum IP-10,AAG,C-reactive protein(CRP)and procalcitonin(PCT)in the infected group were obviously increased(P＜0.05).The ICU stay time,airway opening time,ventilator use time,antibiotic use time,antibiotic type,and the levels of serum IP-10,AAG,CRP and PCT were all risk factors that affecting the occurrence of lower respiratory tract infections in patients(P＜0.05).The AUC of the IP-10,AAG combined prediction was obviously better than IP-10 and AAG alone(P＜0.05).Compared with the mild group,the serum IP-10 and AAG levels in the moderate group and severe group were obviously increased(P＜0.05).The levels of IP-10 and AAG were positively correlated with the severity of the disease(r=0.409,0.428,P＜0.05).Conclusions The ICU stay time,airway opening time,ventilator use time,antibiotic use time,types of antibiotic,and the levels of serum IP-10,AAG,CRP and PCT are risk factors affecting lower respiratory tract infection in ICU tracheostomy patients.Among patients with secondary lower respiratory tract infection after tracheostomy in ICU,serum IP-10 and AAG levels are obviously increased.IP-10 and AAG have certain early auxiliary predictive value for lower respiratory tract infection in patients.
Keywords：intensive care unittracheotomylower respiratory tract infectioninterferon gamma induced protein 10Alpha 1-acidic glycoproteinearly prediction
Publication Date：2025-08-30
Online Publishing Date：2025-08-28(First online date of this platform, not the publication date of the document)
Pages：6( 394-398,402 )