Clinical efficacy of sodium fructose bisphosphate combined with recombinant human interferon α 1b in rotavirus enteritis and effects on the level of myocardial enzyme spectrum in children
SUN Chun
ZHANG Fang
YE Ying
SHU Zhen
HUANG Yamei
Abstract：Objective To investigate the clinical efficacy of fructose-1,6-diphosphate sodium combined with recombinant human interferon α1b in the treatment of rotavirus enteritis and its effect on myocardial enzyme profiles in children.Methods A total of 200 children with rotavirus enteritis complicated with diabetic ketoacidosis admitted to our hospital(San Tai County People's Hospital)from June 2021 to June 2024 were selected.They were divided into a control group and an observation group using a random number table method,with 100 cases in each group.The control group received recombinant human interferon α1b treatment,while the observation group received fructose-1,6-diphosphate sodium combined with recombinant human interferon α1b.The improvement time of clinical symptoms was compared and statistically analyzed between the two groups.Levels of inflammatory factors[Tumor Necrosis Factor Alpha(TNF-α),Interleukin-6(IL-6),High Mobility Group Protein B1(HMGB1)],gastrointestinal function indicators[Gastrin(GAS),Motilin(MTL),Diamine Oxidase(DAO),Intestinal Fatty Acid Binding Protein(I-FABP)],myocardial enzymes[Creatine Kinase(CK),Lactate Dehydrogenase(LDH),Creatine Kinase Isoenzyme(CK-MB)],neural factors[Nerve Growth Factor(NGF),Brain-Derived Neurotrophic Factor(BDNF),Neurotrophic Factors(NTF),Myelin Basic Protein(MBP),Neuron Specific Enolase(NSE)],and T cell subsets[CD4+T cells,CD8+T cells,CD4+/CD8+ratio]were measured.Results After treatment,compared with the control group:The observation group showed significantly shortened clinical symptom improvement time(P＜0.05).Levels of TNF-α,IL-6,HMGB1,MBP,NSE,CD8+T cells,GAS,MTL,DAO,I-FABP,CK,LDH,and CK-MB were significantly reduced(P＜0.05).Levels of NGF,BDNF,NTF,CD4+T cells,and the CD4+/CD8+ratio were significantly higher(P＜0.05).The total effective rate in the observation group was significantly higher than that in the control group(P＜0.05).Conclusion For children with rotavirus enteritis,the treatment regimen of fructose-1,6-diphosphate sodium combined with recombinant human interferon α1b can effectively reduce inflammatory responses,improve gastrointestinal function,alleviate myocardial injury,relieve clinical symptoms,demonstrating significant clinical efficacy.
Keywords：sodium fructose diphosphaterecombinant human interferon α1brotavirus enteritispediatric childmyocardial zymogram
Publication Date：2025-08-30
Online Publishing Date：2025-08-28(First online date of this platform, not the publication date of the document)
Pages：6( 379-384 )