Correlation of between the changes inserum levels of interleukin-8,starch amyloid A protein,and transforming growth factor β1 and the prognosis of children with severe pneumonia caused by H1N1 influenza A
DENG Linlin
SONG Zixia
LI Hongyan
Abstract：Objective To investigate the correlation between the changes in serum levels of Interleukin-8(IL-8),Starch amyloid A protein(SAA),and Transforming growth factor beta 1(TGF-β1)and the prognosis of children with severe pneumonia caused by H1N1 influenza A(H1N1).Methods A total of 202 children with severe pneumonia caused by influenza A(H1N1)from January 2023 to May 2024 were selected and divided into a good prognosis group and a poor prognosis group according to their prognosis.Baseline data,serum levels of IL-8,SAA,and TGF-β1 were compared between the two groups.Pearson correlation coefficient was used to analyze the relationship between serum IL-8,SAA,TGF-β1 and disease severity[Acute Physiology and Chronic Health Evaluation System Ⅱ(APACHE Ⅱ)score,Sequential Organ Failure Assessment(SOFA)score].Logistic regression was used to analyze the independent correlation between serum IL-8,SAA,TGF-β1 and prognosis.Receiver operating characteristic(ROC)curve and area under the curve(AUC)were used to analyze the predictive efficacy of serum IL-8,SAA,and TGF-β1 on prognosis.Results The levels of serum IL-8,SAA,and TGF-β1 in the poor prognosis group were higher than those in the good prognosis group(P<0.05);serum levels of IL-8,SAA,and TGF-β1 were positively correlated with APACHE Ⅱ and SOFA scores(P<0.05);Logistic regression analysis showed that serum IL-8,SAA,and TGF-β1 were independently associated with prognosis after adjusting for other factors(P<0.05);the AUC of serum IL-8,SAA,and TGF-β1 for predicting prognosis was 0.745,0.762,and 0.759,respectively.The AUC of the combination of the three indicators for predicting prognosis was 0.928,which was significantly higher than the predictive efficacy of each indicator alone(z=3.782,3.065,3.103,all P<0.000).Conclusion Serum IL-8,SAA,and TGF-β1 in children with severe pneumonia caused by influenza A(H1N1)are independently associated with prognosis and have independent predictive ability,and the combined predictive performance is higher.
Keywords：H1N1 influenza Asevere pneumoniainterleukin-8starch amyloid A proteintransforming growth factor-β1prognosiscorrelation
Publication Date：2025-06-30
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 235-239 )