Correlation between KL-6,LDH,SAA and IL-6 levels and severity of viral pneumonia in children

XU Chunhua; ZHENG Lingling

doi:10.3969/j.issn.1007-8134.2025.03.005

Abstract：Objective To investigate the correlation between changes in salivary liquefied glycan antigen(KL-6),lactate dehydrogenase(LDH),serum amyloid A(SAA),and interleukin-6(IL-6)levels and the severity of viral pneumonia in children.Methods Fifty cases of children with viral pneumonia admitted to our hospital between March 2022 and March 2023 were selected as study subjects.The severity of viral pneumonia was assessed according to the children's clinical symptoms and imaging data,etc.The children were divided into a mild group and a severe group,with 27 cases in the mild group and 23 cases in the severe group.Two sets of general data and clinically relevant indicators were collected,multivariate logistic regression analysis was used to screen for independent risk factors for the severity of viral pneumonia in children,and ROC curve analysis was used to predict the effectiveness of independent risk factors in predicting the severity of viral pneumonia in children.Results Duration of fever and levels of CD4+T-lymphocytes,KL-6,LDH,SAA,and IL-6 were statistically significant in the severe group compared with the mild group(t=10.719,7.881,51.402,56.190,17.716,14.510,P＜0.05).Prolonged fever duration,low CD4+T levels,high KL-6 levels,high LDH levels,high SAA levels,and high IL-6 levels were all risk factors affecting severe viral pneumonia in children(OR=4.453,5.937,4.121,4.500,5.236,5.115,P＜0.05).The ROC curve results showed that fever duration,CD4+T-lymphocytes,KL-6,LDH,SAA,and IL-6 all had high predictive power(AUC=0.678,0.691,0.666,0.669,0.688,0.672,P＜0.05).Conclusion KL-6,LDH,SAA,and IL-6 levels are significantly increased in children with viral pneumonia,while CD4+T-lymphocytes levels are significantly decreased,and these changes are related to the severity of the disease,providing important predictive value for analyzing the severity of the disease.