Dynamic changes of IP-10 and Th1/Th2 in patients with tuberculous pleurisy and their correlation with pleural thickness and pleural adhesion

LAN Yun; LI Yugang; DONG Qingzhu

doi:10.3969/j.issn.1007-8134.2025.03.004

Abstract：Objective To investigate the changes in interferon-gamma inducible protein 10(IP-10),T helper 1(Th1)/Thelper 2(Th2),Th1/Th2 ratio dynamics in patients with tuberculous pleurisy and their correlation with pleural thickness and pleural adhesion.Methods One hundred six patients with tuberculous pleurisy who received treatment(intensive period of 2 months and consolidation period of 10 months)at Jiaozuo Third People's Hospital from January 2018 to January 2023 were selected as the study subjects,and they were divided into effective(n=77)and ineffective(n=29)groups according to the efficacy of the treatment after 3 months of treatment.The general data,pleural fluid IP-10,Th1/Th2 levels as well as pleural thickness and pleural adhesions were compared between the 2 groups to analyze the correlation between the dynamic changes of IP-10 and Th1/Th2 ratio and pleural thickness and pleural adhesions in patients with pleurisy,as well as the correlation between pleural thickness and pleural adhesions and the efficacy of treatment.Results Compared with the effective group,patients in the ineffective group had greater pleural thickness(P＜0.05)and a higher proportion of pleural adhesions(P＜0.05).No significant differences were observed in other data(P＞0.05).Pleural thickness was strongly correlated with pleural adhesions in patients with tuberculous pleurisy(r=0.867,P＜0.05),and there was a negative correlation between pleural thickness,pleural adhesions,and efficacy(pleural thickness:r=-0.787;pleural adhesions:Phi coefficient=-0.621;P＜0.05).At 1 week,1 month,and 3 months after treatment,the levels of IP-10 and Th1/Th2 in pleural effusion were negatively correlated with pleural thickness and pleural adhesions(P＜0.05).Conclusion The levels of IP-10 and Th1/Th2 in pleural effusion in patients with tuberculous pleurisy are closely related to pleural thickness and pleural adhesions,and they are also correlated with clinical efficacy.The correlation is highest three months after treatment.