Advances in hepatitis B vaccination strategies for people living with HIV
YU Yuanyuan
MU Liying
GAO Pan
NIE Jingmin
Abstract：Hepatitis B vaccination serves as an effective measure for preventing hepatitis B virus(HBV)infection,and current global guidelines strongly recommend hepatitis B vaccination for human immunodeficiency virus(HIV)-infected individuals.However,specific vaccination protocols remain controversial.Approaches such as increasing single-dose vaccine amounts,injection frequencies,or adding vaccine adjuvants can enhance the initial response rate to hepatitis B vaccination among HIV-infected individuals to some extent.Nevertheless,there are no definitive standard for recommended vaccination doses and frequencies tailored to HIV-infected individuals with varying CD4+T lymphocyte levels.Additionally,the long-term protective mechanism of the vaccine for HIV-infected individuals warrant further investigation.This review comprehensively summarizies the efficacy of the hepatitis B vaccination regimen in HIV-infected patients,as well as the roles of specific factors such as vaccination dose and frequency in vaccine responsiveness.
Keywords：HIVHBVhepatitis B vaccineimmune response
Publication Date：2025-04-30
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 203-207 )