Characteristics and risk factors of multidrug-resistant bacterial pulmonary infections in respiratory unit patients:A hospital-based study
YU Liang
LI Wei
ZHANG Meng
Abstract：Objective This study aims to investigate the characteristics and influencing factors of multidrug-resistant bacteria infections in the lungs of hospitalized patients in the respiratory department of the Staff Hospital of China No.19 Metallurgical Group Co.,Ltd.,providing a basis for clinical prevention and control.Methods Using the retrospective research analysis method,162 patients with pulmonary infection who were hospitalized in the respiratory department of the staff hospital of China No.19 Metallurgical Group Co.,Ltd.from January 2020 to February 2024 were selected as the research objects.According to whether they had multidrug-resistant bacteria infection,they were divided into the research group(n=86)and the control group(n=76).The distribution characteristics of pathogenic bacteria in sputum specimens of patients were detected.The drug resistance of multidrug-resistant bacteria was detected by the disk diffusion method.The risk factors of multidrug-resistant bacteria infection were analyzed by multivariate Logistic regression.Results total of 81 pathogenic bacteria strains were isolated from the control group,of which 52 were Gram-negative,accounting for 64.19％,predominantlyPseudomonas aeruginosa(22.22％)and Klebsiella pneumoniae(14.82％);there were 21 Gram-positive bacteria,accounting for 25.93％,mainlyStreptococcus pneumoniae(12.35％);and 8 fungi,accounting for 9.88％In the study group,86 pathogens were isolated,There were 51 Gram-negative bacteria,accounting for 59.30％,primarilyPseudomonas aeruginosa(27.91％)and Acinetobacter baumannii(16.28％);There were 29 Gram-positive bacteria,accounting for 33.72％,mostlyStaphylococcus aureus(20.93％);and 6 fungi,accounting for 6.98％.Multivariate logistic regression analysis revealed that length of stay(OR=2.852,95％CI:1.087-7.481),admission to ICU(OR=2.765,95％CI:1.131-6.758),glucocorticoid treatment(OR=2.702,95％CI:1.217-6.000),mixed infection(OR=2.751,95％CI:1.146-6.607),mechanical ventilation(OR=2.721,95％CI:1.050-7.051),hemoglobin content(OR=0.355,95％CI:0.150-0.841)and antimicrobial drug duration(OR=2.517,95％CI:1.154-5.491)are all associated with the risk of multi-drug-resistant bacterial infections(P＜0.05).Conclusions Multi-drug-resistant bacteria in the pulmonary infection patients are mainly caused by Gram-negative bacteria.Factors such as prolonged hospital stay,ICU admission,and extended antimicrobial drug duration increase the risk of multidrug-resistant bacterial infections.Clinically,multidrug-resistant bacterial infections and targeted preventive measures should be taken based on their distribution characteristics and related risk factors.
Keywords：pulmonary infectionmultidrug-resistant bacteriainfection characteristicsinfluencing factors
Publication Date：2025-04-30
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 186-191 )