Application value of serum ANGPTL4 and cholinesterase levels in diagnosis and severity assessment of Mycoplasma pneumoniae pneumonia in children

ZHOU Ling; YE Haiyan; LIU Yifeng; SHI Qun; TAN Dongqiong; WANG Tongyuan; YAN Jun

doi:10.3969/j.issn.1007-8134.2025.02.014

Abstract：Objective To investigate the relationship between the levels of angiopoietin like protein 4(ANGPTL4),serum cholinesterase(sCHE),and the diagnosis and assessment of Mycoplasma pneumoniae pneumonia(MPP)in children.Methods A total of 80 children with MPP(MPP group)who received medical treatment at Jiulongpo District People's Hospital in Chongqing from January 2023 to January 2024 were selected.The MPP group was further divided into mild and severe groups,and 80 healthy children who underwent physical examinations in the pediatric department of our hospital during the same period were selected(healthy group).The clinical data and relevant testing indicators of each group were compared.Use Logistic regression analysis to analyze the influencing factors of severe MPP in children.Use receiver operating characteristic curve(ROC)to analyze the diagnostic efficacy of serum ANGPTL4 and sCHE levels for the occurrence of misdiagnosis in MPP children.Results Compared with the healthy group,the white blood cell count,C-reactive protein,tumor necrosis factor alpha,and serum ANGPTL4 levels in the MPP group were significantly increased(P＜0.05),while sCHE levels were significantly decreased(P＜0.05);Compared with the mild group,the severe group showed a significant increase in serum ANGPTL4 and a significant decrease in sCHE levels(P＜0.05).The serum ANGPTL4 and sCHE levels in MPP group children were negatively correlated(r=-0.490).The results of logistic regression analysis showed that elevated ANGPTL4 levels and decreased sCHE levels were risk factors for severe MPP in children.The ROC curve analysis results showed that the area under curve(AUC)for diagnosing severe MPP in children with MPP based on serum ANGPTL4 levels was 0.778,with a sensitivity of 63.75％and specificity of 91.25％;The AUC,sensitivity,and specificity of serum sCHE levels in diagnosing severe MPP in children were 0.878,85.00％,and 87.50％,respectively;The AUC,sensitivity,and specificity of the combined diagnosis of serum ANGPTL4 and sCHE for severe MPP in children were 0.920,92.5％,and 82.50％,respectively.Conclusion Serum ANGPTL4 and sCHE can be used for the diagnosis and evaluation of MPP,and the combined diagnosis of ANGPTL4 and sCHE is superior to their individual diagnosis.