Drug resistance patterns of Mycobacterium tuberculosis to first-line anti-tuberculosis drugs in Guizhou area

YE Yang; WU Jia; WANG Mingdong; DENG Wei; REN Tingting

doi:10.3969/j.issn.1007-8134.2025.02.010

Abstract：Objective To understand the general drug susceptibility situation of clinical isolates of Mycobacterium tuberculosis to first-line antituberculosis drugs in Guizhou.Methods Three hundred clinical Mycobacterium tuberculosis isolates from August 2022 to June 2024 at the Guiyang Public Health Treatment Center were collected,and the Bactec-MGIT960 system was used to test their drug susceptibility.The results of their susceptibility to first-line antituberculosis drugs were counted and analyzed.Results Of the 300 clinical Mycobacterium tuberculosis isolates.One hundred and fifty-nine strains were separated from first-treatment patients 141 strains were separated from retreatment patients,82 strains were separated from males and 42 strains were separated from females.The total drug resistance rate was 41.33％,33.33％of that was in primary treatment patients 50.35％was in retreatment patients,and the multidrug resistance rate was 13.00％,7.55％was in first-treatment patients and 19.15％of that was in retreatment patients.Among all Mycobacterium tuberculosis isolates.Isoniazid has the highest resistance rate,accounting for 31.00％,and the resistance rate of ethambutol was the lowest,accounting for 14.67％.Compared with female patients,male patients had a higher drug resistance rate.Among the 3 age groups,30-60 years old had the highest incidence,and the total drug resistance rate of all age groups was significantly different(x2=12.304,P=0.002).Compared with first-treatment patients,the resistance rate of all first-line antituberculosis drugs in retreatment patients is higher than in first-treatment patients.The resistance rate of streptomycin and ethambutol in multidrug-resistant isolates was higher than those in drug-resistant isolates,and there was no significant difference in the resistance rate of pyrazinamide in multidrug-resistant isolates and drug-resistant isolates(P=0.078).Conclusions The drug susceptibility situation of Mycobacterium tuberculosis in Guizhou is complex,and the drug resistance rate and multidrug resistance rate are relatively high.Furthermore,drug resistance is more common in retreated patients.Male patients had a higher drug resistance rate than female patients,and 30-60 years old age groups had the highest incidence.So it is necessary to optimize the treatment plan and rationalize the use of medication,strengthen the management of patients'anti-tuberculosis treatment,so as to reduce drug-resistant tuberculosis.