Association of changes in serum amyloid A and Toll-like receptor 4 with pulmonary infection in patients with hepatitis B cirrhosis
WANG Jinye
LYU Caiyuan
LI Xiaoli
ZHANG Zhanhua
YANG Wen
TIAN Hua
LI Na
Abstract：Objective To investigate the changes of serum amyloid A(SAA)and Toll like receptor 4(TLR4)levels in patients with hepatitis B cirrhosis,and to evaluate the correlation between SAA and TLR4 and pulmonary infection in patients with hepatitis B cirrhosis.Methods One hundred and twenty-four patients with hepatitis B cirrhosis who came to our hospital from June 2020 to June 2023 were divided into infected group(n=31)and uninfected group(n=93)according to whether infection occurred.The correlation between SAA and TLR4 levels and pulmonary infection in patients with hepatitis B cirrhosis was compared,and the receiver operating ROC curve was drawn.The predictive value of SAA and TLR4 levels for pulmonary infection in patients with hepatitis B cirrhosis was evaluated.Result SAA(56.82±4.63)mg/L and TLR4(5.93±0.54)ng/mL in the infected group were significantly higher than those in the uninfected group(P＜0.05).Spearman correlation analysis showed that SAA and TLR4 levels were positively correlated with pulmonary infection in patients with hepatitis B cirrhosis(P＜0.05).ROC analysis showed that the areas under SAA,TLR4 and combined factor curves were 0.834,0.769 and 0.923,respectively.Conclusion SAA and TLR4 are highly expressed in patients with hepatitis B cirrhosis complicated with pulmonary infection.SAA combined with TLR4 has a high application prospect in evaluating and predicting pulmonary infection in patients with hepatitis B cirrhosis.
Keywords：serum amyloid AToll-like receptor 4hepatitis B cirrhosispulmonary infection
Publication Date：2025-02-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 22-25 )