Changes of Mycoplasma pneumoniae RNA,IL-17A and IL-12p70 levels in children with Mycoplasma pneumoniae pneumonia
HAO Xiaoyan
TIAN Hui
YANG Shengmei
JIA Fang
QI Jie
XUE Qin
LI Li
WU Jieping
WANG Sumin
Abstract：Objective To explore the changes and significance of Mycoplasma pneumoniae ribonucleic acid(RNA),06-17A,and IL-12p70 levels in children with Mycoplasma pneumoniae pneumonia.Methods A total of 149 hospitalized children with pneumonia in Shanxi Childen's Hospital from January 2022 to May 2024 were selected and divided into non MPP group(64 cases,MP culture negative)and the MPP group(85 cases,MP culture positive).The MP RNA detection results of 149 children with pneumonia were compared with MP culture results,and the serum levels of IL-17A and IL-12p70 in the MPP and non-MPP groups were detected and compared.All children with MPP were treated with a conventional regimen for 28 d The MP RNA positive detection rate and serum IL-17A,IL-12p70 levels at different treatment time points(before treatment,7 d,14 d,21 d,28 d)were analyzed.The MP RNA positive detection rate and serum IL-17A and IL-12p70 levels in children with MPP with different clinical efficacy were compared.Results Among 149 children with pneumonia,85 cases were clinically diagnosed as MPP(MP Culture).When MP RNA was used to detect Mycoplasma pneumonia,the positive detection rate was 89.41％(76/85).The serum levels of IL-17A and IL-12p70 in the MPP group were significantly higher than those in non-MPP group(P＜0.05).The positive detection rate of MP RNA and serum IL-17A and IL-12p70 levels gradually decreased with the extension of treatment time in children with MPP(P＜0.05).The positive detection rate of MP RNA and the levels of serum IL-17A and IL-12p70 in the ineffective group were significantly higher than those in the effective group(P＜0.05).Conclusion In children with pneumonia,the serum levels of IL-17A and IL-12p70 in children with MPP were significantly higher,and the serum levels of IL-17A and IL-12p70 gradually decreased after treatment,which was closely related to the curative effect of MPP.
Keywords：Mycoplasma pneumoniae RNAinterleukin-17Ainterleukin-12p70childrenMycoplasma pneumoniae pneumonia
Publication Date：2024-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 532-535 )