Analysis of clinical characteristics in severe fever with thrombocytopenia syndrome and hemorrhagic fever with renal syndrome

XUE Xiaoyu; WANG Xiaolei; NIU Wenjing; DUAN Jianping; LIN Ling; CHEN Zhihai

doi:10.3969/j.issn.1007-8134.2024.05.012

Abstract：Objective To compare the differences in epidemiological,clinical,and laboratory parameters between patients with Severe Fever with Thrombocytopenia Syndrome(SFTS)and Hemorrhagic Fever with Renal Syndrome(HFRS),which may improve clinical knowledge of both diseases and reduce misdiagnoses.Methods Two hundred and nineteen patients with SFTS(SFTS group)and 201 patients with HFRS(HFRS group)admitted to Yantai Qishan Hospital and Qingdao No.6 People's Hospital from January 2021 to December 2023 were retrospectively analyzed.Independent samples t-tests,analysis of variance(ANOVA),and chi-square tests were used to compare differences in the epidemiological parameters,clinical manifestations and laboratory indicators between the 2 groups.A random forest model to distinguish the two diseases was established.Results Epidemiological parameters that differed between SFTS and HFRS patients were age,sex,season of onset,exposure history,prognosis,and degree of disease;clinical manifestations that differed between SFTS and HFRS patients were conjunctival hemorrhage,skin petechiae and ecchymosis,lumbar pain,orbital pain,oliguria,neurological symptoms,and renal regional percussion pain;laboratory parameters that differed between SFTS and HFRS patients were white blood cell count,prothrombin time,aspartate transaminase,creatinine,blood urea nitrogen,creatine kinase,and proteinuria.The top 5 parameters screened by the random forest model were white blood cell count stratification,C-reactive protein,disease typing,creatinine,and mucosal hemorrhage.Conclusions Patients with SFTS were more prone to myocardial,liver,and central nervous system damage compared to HFRS patients.HFRS patient were more likely to exhibit renal damage.