Clinical features of chronic hepatitis B combined with primary biliary cholangitis
YANG Xue
MAO Huitong
XU Bin
LIU Yanmin
LIN Xiao
ZHAO Juan
HUANG Chunyang
Abstract：Objective To observe the clinical features and prognosis of 24 patients with chronic hepatitis B(CHB)combined with primary biliary cholangitis(PBC).Methods Patients with CHB combined with PBC attending Beijing You'an Hospital affiliated with Capital Medical University from January 2010 to December 2022 were selected.All patients initially presented to our hospital with CHB.Results In 24 patients,16 were women and 8 were men,with 66.7 percent women.Thirteen had symptoms of yellowing or itching,16 had abnormal liver function,predominantly elevated alkaline phosphatase(ALP)and r-glutamyl transpeptidase(γ-GT),and 24 patients were positive for anti-mitochondrial antibodies(AMA).ALP and γ-GT decreased significantly in 24 patients treated with antiviral and UDCA(P=0.003.P=0.004).Conclusion Treatment with antiviral and ursodeoxycholic acid in patients with CHB combined with PBC did not affect their biochemical response or prognosis.
Keywords：primary biliary cholangitischronic hepatitis Bclinical featuresprognosis
Publication Date：2024-10-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 415-417,423 )