The correlation between serum LN,SPE and the severity of liver cirrhosis and their prediction for mild hepatic encephalopathy
YAN Zhaolan
LI Yajing
DENG Jinhua
Xie Yujin
Abstract：Objective To explore the correlation between serum laminin (LN),protein electrophoresis (SPE) and the severity of liver cirrhosis,and their predictive value for mild hepatic encephalopathy. Method Two hundred patients with liver cirrhosis admitted to our hospital from January 2020 to January 2024 were selected as the research subjects. The severity of liver cirrhosis was determined by Child Pugh grading for all patients,with 46 cases classified as A,90 cases classified as B,and 64 cases classified as C. Compare the expression levels of serum laminin and SPE in patients with different Child Pugh grades,and use Spearman correlation analysis to analyze the correlation between laminin,SPE and the severity of liver cirrhosis. Subsequently,200 patients with cirrhosis were divided into two groups based on whether they had mild hepatic encephalopathy or not,namely the hepatic encephalopathy group (n=35) and the non hepatic encephalopathy group (n=165). Compared with the general clinical data,the expression level of LN and SPE,logistics regression model analyzed the influencing factors of cirrhosis with mild hepatic encephalopathy,and established ROC curve to analyze the predictive value of LN and SPE with mild hepatic encephalopathy. Result The comparison of serum LN and SPE levels among patients in Class A,Class B,and Class C groups showed statistically significant differences. The levels of gamma globulin,α 1-globulin,and LN in patients with grade C were higher than those in patients with grade B and grade A,while the levels of beta globulin,α 2-globulin,and albumin in patients with grade C were lower than those in patients with grade B and grade A (P<0.05);The Spearman correlation analysis results showed that γ-globulin,α 1-globulin,and LN were positively correlated with the severity of liver cirrhosis,while β-globulin,α 2-globulin,and albumin were negatively correlated with the severity of liver cirrhosis (P<0.05);There were significant differences (P<0.05) in Child Pugh grading,hepatorenal syndrome,ascites,electrolyte imbalance,infection,blood ammonia,and total bilirubin levels between patients with hepatic encephalopathy and those without hepatic encephalopathy;There was no significant difference in the levels of α 1-globulin and albumin related serum SPE between the hepatic encephalopathy group and the non hepatic encephalopathy group (P>0.05),while there were significant differences in the levels of γ-globulin,β-globulin,α 2-globulin related serum SPE and LN between the hepatic encephalopathy group and the non hepatic encephalopathy group (P<0.05);The combined electrolyte disorder,co-infection,γ-globulin,β-globulin,α2-globulin related serum SPE and LN were the influencing factors for the occurrence of mild hepatic encephalopathy with cirrhosis (P<0.05);the prediction value of LN and SPE on cirrhosis with mild hepatic encephalopathy was 93.54％,85.45％,and the combined prediction was significantly higher than the single diagnosis (P<0.05). Conclusion Serum LN and SPE are closely related to the severity of liver cirrhosis,and in addition to the increased risk of mild hepatic encephalopathy caused by electrolyte disorders and co infection,serum LN and SPE can predict the occurrence of mild hepatic encephalopathy early.
Keywords：laminin proteinprotein electrophoresisliver cirrhosischild push gradingmild hepatic encephalopathypredictive value
Publication Date：2024-08-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 329-334 )