Serum YKL-40 and HBD-2 levels in patients with pulmonary tuberculosis and their diagnostic value for pulmonary tuberculosis
LI Chunxiao
LI Huaichen
Abstract：Objective To explore the serum levels of chitinase protein 40(YKL-40)and human beta defensin 2(HBD-2)in patients with pulmonary tuberculosis and their diagnostic value.Methods From June 2021 to June 2023,86 confirmed pulmonary tuberculosis patients admitted in Shandong Provincial Hospital were included in the pulmonary tuberculosis group.They were separated into active pulmonary tuberculosis group(n=50)and non active pulmonary tuberculosis group(n=36)according to sputum smear results.An additional 86 healthy subjects from the same hospital's physical examination center were selected as the control group.Detect and analyze the levels of YKL-40 and HBD-2 in the serum of all subjects.Analyze the correlation between YKL-40 and HBD-2 in the serum of patients with pulmonary tuberculosis.ROC curve was applied to analyze the diagnostic value of serum YKL-40 and HBD-2 levels for pulmonary tuberculosis and active pulmonary tuberculosis.Results Compared with the control group,the serum levels of YKL-40 and HBD-2 in the pulmonary tuberculosis group were significantly increased(P＜0.05).Compared with inactive pulmonary tuberculosis group,the levels of serum YKL-40 and HBD-2 in active pulmonary tuberculosis group were significantly higher(P＜0.05).The serum levels of YKL-40 and HBD-2 in patients with pulmonary tuberculosis were positively correlated(r=0.601).The area under the curve(AUC)of YKL-40,HBD-2,and their combination in the diagnosis of pulmonary tuberculosis was 0.895,0.922,and 0.962,respectively,the combination of the 2 was superior to single diagnosis.The AUC of YKL-40,HBD-2,and their combination in the diagnosis of active pulmonary tuberculosis was 0.891,0.881,and 0.959,respectively,the combination of the 2 was superior to single diagnosis.Conclusion The serum levels of YKL-40 and HBD-2 are obviously elevated in patients with pulmonary tuberculosis,which are positively correlated with the severity of disease,and their levels have certain diagnostic value for pulmonary tuberculosis and active pulmonary tuberculosis.
Keywords：pulmonary tuberculosischitinase protein 40human beta defensin 2diagnosis
Publication Date：2024-04-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 142-146 )